Platelet Rich Fibrin

Platelet Rich Fibrin


PRF bears some similarities to the popular PRP treatment used in skin restoration procedures.  In PRF, blood is drawn from the patient and centrifuged at slower speeds than in a PRP (platelet-rich plasma). 

The absence of an anticoagulant in the tube allows the formation of a spongy, gel-like product rich in platelets, growth factors, and fibrin that can be injected into the skin to address signs of aging by promoting collagen production, hair loss, or skin healing.  

You can expect this entire procedure to last anywhere from 20-45 minutes, depending on the location you’re getting injected. You might need anywhere from three to five treatments to see results.


As we mentioned earlier, PRF injections are similar to another type of injection, PRP injections. PRP injections are typically used for athletes undergoing treatment for injuries or to help them recover from injuries quicker.

PRF is plasma rich fibrin. PRP is plasma-rich platelets. PRP is spun at a much higher rate in the centrifuge, therefore, most of the cells—white cells, blood cells, etc., are kept at the bottom of the tube and the lighter cells, the platelets, are kept in the serum and the top level after spinning.

PRF, on the other hand, is spun at a slower rate, so a lot of the white cells, and platelets are kept in the top layers of the post-centrifuge tube, while the red cells will make their way down to the bottom. That is what is injected into the tissues, as opposed to just platelets and serum. There would be potentially more growth factors effect in the PRF treatments, as opposed to PRP.


As is the case with all injections, there is always a risk of redness, bruising, and pain caused by the needle used as can redness and swelling. A headache is sometimes reported after injections into the scalp.

PRF under your eyes, specifically, you should expect some swelling and/or puffiness that can last about three to five days to resolve. 


If you do have any discomfort, you can treat it using a cold compress and an over-the-counter pain medication like acetaminophen.  Avoid excessive sun exposure 24he after treatment and make sure you apply SPF appropriate sun screen a day after treatment.


You will begin to see the results of your treatment become noticeable around the one-to-two-month mark, as the structures and collagen under the eye continue to build.

Optimal results would typically require three to six treatments and results typically last one to two years.


If you have any aversion to blood or are needle phobia or getting your blood drawn, this is maybe where you’re going to reconsider getting PRF injections, as the procedure.


At MonaLisa Medical Spa, PRF treatment is sold for $1000 per session